The pomegranate extract possesses strong antioxidant and anti-inflammatory activities linked to the presence of anthocyanins, ellagic tannins, and hydrolyzable tannins. Recent researches show that the pomegranate polyphenols are important in preventing cardiovascular diseases and significantly decrease the thickness of the carotid intima-media. Furthermore, a high decrease in blood pressure, process of atherosclerosis, and its ability to increase HDL cholesterol were observed. Clinical studies show its effectiveness against certain cancers, particularly prostate cancer. The efficacy of pomegranate juice is mainly due to its high bioavailability compared to other polyphenols such as resveratrol.