Effect of pomegranate extract (PFE) in human radiodermatitis patients with squamous cell carcinoma (SCC) after radiotherapy
Studies carried out by the authors and other research groups have shown that pomegranate extract and other naturally occurring antioxidants, such as centella aciatica and green tea are effective in reducing the adverse effects of UVA/UVB or linear accelerator-mediated cutaneous damage. In addition pomegranate extract protects the skin by inhibiting UVB- and UVA-induced modulations of NF-kB and MAP kinase pathways. Our data suggest that the mechanism of the photochemopreventive effect of pomegranate extract against X-ray mediated damage is possibly similar to that demonstrated with UVB, UVA ionizing radiation
Thus the present study revealed that the gallic acid isolated from the pomegranate peel extract induced apoptosis in A549 cells through intrin-sic pathway.
The pomegranate juice treatment effectively reduced the oxidative stress and contributed to tissue recovery in experimental diabetic lungs. These findings would be of clinical relevance.
Regarding promising prospects of pomegranate phenolics, this review summarizes the available scientific information related to health promotion features of pomegranate-derived products and underlines the influence of multiple constituents on the observed biological actions, pointing out pomegranate juice as an interesting source to obtain health benefits.
Dr. A.E. Dujally scientist of Queen Marget University isolates Punicalagins from pomegranate seed, pulp, etc. Punicalagins is very effective in the treatment of infertility, heart disease, cancer, high blood pressure and several others. Their isolation is a mile stone of plant medicine after isolation of aspirin (also known as acetylsalicylic acid or ASA) from willow plant. Aspirin also has analgesic, anti-inflammatory, antiplatelet [prevent clotting diseases (such as heart attacks and strokes)] and antipyretic properties. It is also effective against 8-OXO-DG compound, which is related to aging. Punicalagins are tannins, large polyphenol compounds which are isomers of 2,3-(S)-hexahydroxydiphenoyl-4,6-(S,S)-gallagyl-D-glucose, hydrolysable tannins with a Molecular formula C48H28O30 and molecular weight of 1084 g/mol. They are found in forms alpha and beta in pomegranates. Punicalagins are also found to be the major component responsible for pomegranate juice's antioxidant and health benefits. Punicalagins are water soluble and have high bioavailability.
In conclusion, these observations suggest that pomegranate extract flower supplementation decreases oxidative stress and ameliorates impairment in learning and memory performances in diabetic rats. Therefore, we suggest that pomegranate extrac flower supplementation may be clinically useful in treating neuronal deficit in diabetic patients.
Pomegranate fruit extract derived from the tree Punica granatum possesses strong antioxidant and antiinflammatory properties. Pomegranate fruit was extracted with acetone and analyzed based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and found to contain anthocyanins, ellagitannins and hydrolyzable tannins
Pomegranate juice supplementation to mice with advanced atherosclerosis reduced their macrophage oxidative stress, their macrophage cholesterol flux and even attenuated the development of atherosclerosis. Moreover, a tannin-fraction isolated from Pomegranate juice had a significant antiatherosclerotic activity.
The overall results showed that the pomegranate peel extracts have both antioxidant and antimutagenic properties and may be exploited as biopreservatives in food applications and neutraceuticals.
The phytochemistry and pharmacological actions of all pomegranate Punica granatum components suggest a wide range of clinical applications for the treatment and prevention of cancer, as well as other diseases where chronic inflammation is believed to play an essential etiologic role
